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Erythromelalgia Mutation Q875E Stabilizes the Activated State of Sodium Channel Nav1.7
The human voltage-gated sodium channel Nav1.7 plays a crucial role in transmission of noxious stimuli. The inherited pain disorder erythromelalgia (IEM) has been linked to Nav1.7 gain-of-function mutations. Here we show that the IEM-associated Q875E mutation located on the pore module of Nav1.7 prod...
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| 發表在: | J Biol Chem |
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| Main Authors: | , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
American Society for Biochemistry and Molecular Biology
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4358268/ https://ncbi.nlm.nih.gov/pubmed/25575597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.605899 |
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