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Erythromelalgia Mutation Q875E Stabilizes the Activated State of Sodium Channel Nav1.7

The human voltage-gated sodium channel Nav1.7 plays a crucial role in transmission of noxious stimuli. The inherited pain disorder erythromelalgia (IEM) has been linked to Nav1.7 gain-of-function mutations. Here we show that the IEM-associated Q875E mutation located on the pore module of Nav1.7 prod...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Stadler, Theresa, O'Reilly, Andrias O., Lampert, Angelika
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2015
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358268/
https://ncbi.nlm.nih.gov/pubmed/25575597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.605899
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