The BRCA1 Tumor Suppressor Binds to Inositol 1,4,5-Trisphosphate Receptors to Stimulate Apoptotic Calcium Release

The inositol 1,4,5-trisphosphate receptor (IP(3)R) is a ubiquitously expressed endoplasmic reticulum (ER)-resident calcium channel. Calcium release mediated by IP(3)Rs influences many signaling pathways, including those regulating apoptosis. IP(3)R activity is regulated by protein-protein interactio...

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Vydáno v:J Biol Chem
Hlavní autoři: Hedgepeth, Serena C., Garcia, M. Iveth, Wagner, Larry E., Rodriguez, Ana M., Chintapalli, Sree V., Snyder, Russell R., Hankins, Gary D. V., Henderson, Beric R., Brodie, Kirsty M., Yule, David I., van Rossum, Damian B., Boehning, Darren
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2015
Témata:
Signal Transduction
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358148/
https://ncbi.nlm.nih.gov/pubmed/25645916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611186
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