The BRCA1 Tumor Suppressor Binds to Inositol 1,4,5-Trisphosphate Receptors to Stimulate Apoptotic Calcium Release

The inositol 1,4,5-trisphosphate receptor (IP(3)R) is a ubiquitously expressed endoplasmic reticulum (ER)-resident calcium channel. Calcium release mediated by IP(3)Rs influences many signaling pathways, including those regulating apoptosis. IP(3)R activity is regulated by protein-protein interactio...

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Detalles Bibliográficos
Publicado en:J Biol Chem
Main Authors: Hedgepeth, Serena C., Garcia, M. Iveth, Wagner, Larry E., Rodriguez, Ana M., Chintapalli, Sree V., Snyder, Russell R., Hankins, Gary D. V., Henderson, Beric R., Brodie, Kirsty M., Yule, David I., van Rossum, Damian B., Boehning, Darren
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2015
Assuntos:
Signal Transduction
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358148/
https://ncbi.nlm.nih.gov/pubmed/25645916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611186
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