The BRCA1 Tumor Suppressor Binds to Inositol 1,4,5-Trisphosphate Receptors to Stimulate Apoptotic Calcium Release

The inositol 1,4,5-trisphosphate receptor (IP(3)R) is a ubiquitously expressed endoplasmic reticulum (ER)-resident calcium channel. Calcium release mediated by IP(3)Rs influences many signaling pathways, including those regulating apoptosis. IP(3)R activity is regulated by protein-protein interactio...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Hedgepeth, Serena C., Garcia, M. Iveth, Wagner, Larry E., Rodriguez, Ana M., Chintapalli, Sree V., Snyder, Russell R., Hankins, Gary D. V., Henderson, Beric R., Brodie, Kirsty M., Yule, David I., van Rossum, Damian B., Boehning, Darren
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Signal Transduction
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358148/
https://ncbi.nlm.nih.gov/pubmed/25645916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.611186
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