Mechanisms Mediating Enhanced Neutralization Efficacy of Staphylococcal Enterotoxin B by Combinations of Monoclonal Antibodies

Staphylococcal enterotoxin B (SEB) is a superantigen that cross-links the major histocompatibility complex class II and specific V-β chains of the T-cell receptor, thus forming a ternary complex. Developing neutralizing mAb to disrupt the ternary complex and abrogate the resulting toxicity is a majo...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Dutta, Kaushik, Varshney, Avanish K., Franklin, Matthew C., Goger, Michael, Wang, Xiaobo, Fries, Bettina C.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2015
Teme:
Immunology
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358096/
https://ncbi.nlm.nih.gov/pubmed/25572397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.630715
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