Quantitative Analysis of Purine Nucleotides Indicates That Purinosomes Increase de Novo Purine Biosynthesis

Enzymes in the de novo purine biosynthesis pathway are recruited to form a dynamic metabolic complex referred to as the purinosome. Previous studies have demonstrated that purinosome assembly responds to purine levels in culture medium. Purine-depleted medium or 2-dimethylamino-4,5,6,7-tetrabromo-1H...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Zhao, Hong, Chiaro, Christopher R., Zhang, Limin, Smith, Philip B., Chan, Chung Yu, Pedley, Anthony M., Pugh, Raymond J., French, Jarrod B., Patterson, Andrew D., Benkovic, Stephen J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2015
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358094/
https://ncbi.nlm.nih.gov/pubmed/25605736
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.628701
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