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Targeted Disruption of Glycogen Synthase Kinase 3a (Gsk3a) in Mice Affects Sperm Motility Resulting in Male Infertility

The signaling enzyme glycogen synthase kinase 3 (GSK3) exists as two isoforms—GSK3A and GSK3B. Protein phosphorylation by GSK3 has important signaling roles in several cells. In our past work, we found that both isoforms of GSK3 are present in mouse sperm and that catalytic GSK3 activity correlates...

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Detalhes bibliográficos
Publicado no:Biol Reprod
Main Authors: Bhattacharjee, Rahul, Goswami, Suranjana, Dudiki, Tejasvi, Popkie, Anthony P., Phiel, Christopher J., Kline, Douglas, Vijayaraghavan, Srinivasan
Formato: Artigo
Idioma:Inglês
Publicado em: Society for the Study of Reproduction, Inc. 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358024/
https://ncbi.nlm.nih.gov/pubmed/25568307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.114.124495
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