Targeted Disruption of Glycogen Synthase Kinase 3a (Gsk3a) in Mice Affects Sperm Motility Resulting in Male Infertility

The signaling enzyme glycogen synthase kinase 3 (GSK3) exists as two isoforms—GSK3A and GSK3B. Protein phosphorylation by GSK3 has important signaling roles in several cells. In our past work, we found that both isoforms of GSK3 are present in mouse sperm and that catalytic GSK3 activity correlates...

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Bibliographic Details
Published in:Biol Reprod
Main Authors: Bhattacharjee, Rahul, Goswami, Suranjana, Dudiki, Tejasvi, Popkie, Anthony P., Phiel, Christopher J., Kline, Douglas, Vijayaraghavan, Srinivasan
Format: Artigo
Language:Inglês
Published: Society for the Study of Reproduction, Inc. 2015
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Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4358024/
https://ncbi.nlm.nih.gov/pubmed/25568307
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.114.124495
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