Inhibition of HCV translation by disrupting the structure and interactions of the viral CRE and 3′ X-tail

A phylogenetically conserved RNA structure within the NS5B coding region of hepatitis C virus functions as a cis-replicating element (CRE). Integrity of this CRE, designated SL9266 (alternatively 5BSL3.2), is critical for genome replication. SL9266 forms the core of an extended pseudoknot, designate...

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Veröffentlicht in:Nucleic Acids Res
Hauptverfasser: Tuplin, Andrew, Struthers, Madeleine, Cook, Jonathan, Bentley, Kirsten, Evans, David J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2015
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357731/
https://ncbi.nlm.nih.gov/pubmed/25712095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkv142
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