HCV IRES interacts with the 18S rRNA to activate the 40S ribosome for subsequent steps of translation initiation

Previous analyses of complexes of 40S ribosomal subunits with the hepatitis C virus (HCV) internal ribosome entry site (IRES) have revealed contacts made by the IRES with ribosomal proteins. Here, using chemical probing, we show that the HCV IRES also contacts the backbone and bases of the CCC tripl...

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Hauptverfasser: Malygin, Alexey A., Kossinova, Olga A., Shatsky, Ivan N., Karpova, Galina G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2013
Schlagworte:
RNA
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3794592/
https://ncbi.nlm.nih.gov/pubmed/23873958
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkt632
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