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Sustained β-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes
Fibrosis is an end-stage response to tissue injury that is associated with loss of organ function as a result of excess extracellular matrix (ECM) production by fibroblasts. In skin, pathologic fibrosis is evident during keloid scar formation, systemic sclerosis (SSc), and morphea. Dermal fibroblast...
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| Pubblicato in: | J Pathol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4357547/ https://ncbi.nlm.nih.gov/pubmed/25385294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4481 |
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