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Sustained β-catenin activity in dermal fibroblasts promotes fibrosis by up-regulating expression of extracellular matrix protein-coding genes

Fibrosis is an end-stage response to tissue injury that is associated with loss of organ function as a result of excess extracellular matrix (ECM) production by fibroblasts. In skin, pathologic fibrosis is evident during keloid scar formation, systemic sclerosis (SSc), and morphea. Dermal fibroblast...

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Detalhes bibliográficos
Publicado no:J Pathol
Main Authors: Hamburg, Emily, DiNuoscio, Gregg J., Mullin, Nathaniel K., Lafayatis, Robert, Atit, Radhika P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357547/
https://ncbi.nlm.nih.gov/pubmed/25385294
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/path.4481
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