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Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Dihydrobiopterin in Adult Falciparum Malaria: Association with Disease Severity, Impaired Microvascular Function and Increased Endothelial Activation
Tetrahydrobiopterin (BH(4)) is a co-factor required for catalytic activity of nitric oxide synthase (NOS) and amino acid-monooxygenases, including phenylalanine hydroxylase. BH(4) is unstable: during oxidative stress it is non-enzymatically oxidized to dihydrobiopterin (BH(2)), which inhibits NOS. D...
Wedi'i Gadw mewn:
| Cyhoeddwyd yn: | PLoS Pathog |
|---|---|
| Prif Awduron: | , , , , , , , , |
| Fformat: | Artigo |
| Iaith: | Inglês |
| Cyhoeddwyd: |
Public Library of Science
2015
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| Pynciau: | |
| Mynediad Ar-lein: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4357386/ https://ncbi.nlm.nih.gov/pubmed/25764397 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004667 |
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