Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Dihydrobiopterin in Adult Falciparum Malaria: Association with Disease Severity, Impaired Microvascular Function and Increased Endothelial Activation

Tetrahydrobiopterin (BH(4)) is a co-factor required for catalytic activity of nitric oxide synthase (NOS) and amino acid-monooxygenases, including phenylalanine hydroxylase. BH(4) is unstable: during oxidative stress it is non-enzymatically oxidized to dihydrobiopterin (BH(2)), which inhibits NOS. D...

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Publicado en:PLoS Pathog
Autores principales: Yeo, Tsin W., Lampah, Daniel A., Kenangalem, Enny, Tjitra, Emiliana, Price, Ric N., Weinberg, J. Brice, Hyland, Keith, Granger, Donald L., Anstey, Nicholas M.
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357386/
https://ncbi.nlm.nih.gov/pubmed/25764397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004667
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