Impaired Systemic Tetrahydrobiopterin Bioavailability and Increased Oxidized Biopterins in Pediatric Falciparum Malaria: Association with Disease Severity

Decreased bioavailability of nitric oxide (NO) is a major contributor to the pathophysiology of severe falciparum malaria. Tetrahydrobiopterin (BH(4)) is an enzyme cofactor required for NO synthesis from L-arginine. We hypothesized that systemic levels of BH4 would be decreased in children with cere...

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Vydáno v:PLoS Pathog
Hlavní autoři: Rubach, Matthew P., Mukemba, Jackson, Florence, Salvatore, Lopansri, Bert K., Hyland, Keith, Volkheimer, Alicia D., Yeo, Tsin W., Anstey, Nicholas M., Weinberg, J. Brice, Mwaikambo, Esther D., Granger, Donald L.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2015
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4357384/
https://ncbi.nlm.nih.gov/pubmed/25764173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1004655
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