PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation

Glioma relies on glycolysis to obtain energy and sustain its survival under low glucose microenvironment in vivo. The mechanisms on glioma cell glycolysis regulation are still unclear. Signaling mediated by Double-stranded RNA-activated protein kinase (PKR) – like ER kinase (PERK) is one of the impo...

Full description

Saved in:
Bibliographic Details
Published in:Sci Rep
Main Authors: Hou, Xu, Liu, Yaohua, Liu, Huailei, Chen, Xin, Liu, Min, Che, Hui, Guo, Fei, Wang, Chunlei, Zhang, Daming, Wu, Jianing, Chen, Xiaofeng, Shen, Chen, Li, Chenguang, Peng, Fei, Bi, Yunke, Yang, Zhuowen, Yang, Guang, Ai, Jing, Gao, Xin, Zhao, Shiguang
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2015
Subjects:
Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356960/
https://ncbi.nlm.nih.gov/pubmed/25761777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09065
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items