PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation

Glioma relies on glycolysis to obtain energy and sustain its survival under low glucose microenvironment in vivo. The mechanisms on glioma cell glycolysis regulation are still unclear. Signaling mediated by Double-stranded RNA-activated protein kinase (PKR) – like ER kinase (PERK) is one of the impo...

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Publicat a:Sci Rep
Autors principals: Hou, Xu, Liu, Yaohua, Liu, Huailei, Chen, Xin, Liu, Min, Che, Hui, Guo, Fei, Wang, Chunlei, Zhang, Daming, Wu, Jianing, Chen, Xiaofeng, Shen, Chen, Li, Chenguang, Peng, Fei, Bi, Yunke, Yang, Zhuowen, Yang, Guang, Ai, Jing, Gao, Xin, Zhao, Shiguang
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356960/
https://ncbi.nlm.nih.gov/pubmed/25761777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09065
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