PERK silence inhibits glioma cell growth under low glucose stress by blockage of p-AKT and subsequent HK2's mitochondria translocation

Glioma relies on glycolysis to obtain energy and sustain its survival under low glucose microenvironment in vivo. The mechanisms on glioma cell glycolysis regulation are still unclear. Signaling mediated by Double-stranded RNA-activated protein kinase (PKR) – like ER kinase (PERK) is one of the impo...

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Publicado no:Sci Rep
Main Authors: Hou, Xu, Liu, Yaohua, Liu, Huailei, Chen, Xin, Liu, Min, Che, Hui, Guo, Fei, Wang, Chunlei, Zhang, Daming, Wu, Jianing, Chen, Xiaofeng, Shen, Chen, Li, Chenguang, Peng, Fei, Bi, Yunke, Yang, Zhuowen, Yang, Guang, Ai, Jing, Gao, Xin, Zhao, Shiguang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356960/
https://ncbi.nlm.nih.gov/pubmed/25761777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09065
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