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Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms
Cardiac dysfunction is a prominent cause of mortality in myotonic dystrophy I (DM1), a disease where expanded CUG repeats bind and disable the muscleblind-like family of splice regulators. Deletion of muscleblind-like 1 (Mbnl1(ΔE2/ΔE2)) in 129 sv mice results in QRS, QTc widening, bundle block and S...
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| 發表在: | Sci Rep |
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| Main Authors: | , , , , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Nature Publishing Group
2015
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4356957/ https://ncbi.nlm.nih.gov/pubmed/25761764 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09042 |
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