Loss of muscleblind-like 1 results in cardiac pathology and persistence of embryonic splice isoforms

Cardiac dysfunction is a prominent cause of mortality in myotonic dystrophy I (DM1), a disease where expanded CUG repeats bind and disable the muscleblind-like family of splice regulators. Deletion of muscleblind-like 1 (Mbnl1(ΔE2/ΔE2)) in 129 sv mice results in QRS, QTc widening, bundle block and S...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Dixon, Donald M., Choi, Jongkyu, El-Ghazali, Ayea, Park, Sun Young, Roos, Kenneth P., Jordan, Maria C., Fishbein, Michael C., Comai, Lucio, Reddy, Sita
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356957/
https://ncbi.nlm.nih.gov/pubmed/25761764
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep09042
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