Regulation of Glutamine Carrier Proteins by RNF5 Determines Breast Cancer Response to ER Stress-inducing Chemotherapies

Many tumor cells are fueled by altered metabolism and increased glutamine (Gln) dependence. We identify regulation of the L-glutamine carrier proteins SLC1A5 and SLC38A2 (SLC1A5/38A2) by the ubiquitin ligase RNF5. Paclitaxel-induced ER stress to breast cancer (BCa) cells promotes RNF5 association, u...

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Veröffentlicht in:Cancer Cell
Hauptverfasser: Jeon, Young Joo, Khelifa, Sihem, Ratnikov, Boris, Scott, David A., Feng, Yongmei, Parisi, Fabio, Ruller, Chelsea, Lau, Eric, Kim, Hyungsoo, Brill, Laurence M., Jiang, Tingting, Rimm, David, Cardiff, Robert D., Mills, Gordon B., Smith, Jeffrey W., Osterman, Andrei L., Kluger, Yuval, Ronai, Ze'ev A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356903/
https://ncbi.nlm.nih.gov/pubmed/25759021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2015.02.006
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