Drug-inducible synergistic gene silencing with multiple small hairpin RNA molecules for gene function study in animal model

Gene targeting is a critical tool for construction of disease models. However, the application of traditional homologous recombination-mediated gene knockout technology is limited by the absence of rapid frequency-guaranteed targeting methods. Although conventional small hairpin RNA (shRNA)-mediated...

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Bibliographische Detailangaben
Veröffentlicht in:Transgenic Res
Hauptverfasser: Ying, Ming, Chen, Guangfeng, Qiu, Yu, Shi, Xiujuan, Zhang, Chen, Wang, Qiuke, Yang, Shuzhang, Lu, Lixia, Yuan, Qionglan, Xu, Guotong, Jin, Zibing, Wu, Qiang, Liu, Xiaoqing
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer International Publishing 2014
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356887/
https://ncbi.nlm.nih.gov/pubmed/25271076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11248-014-9841-9
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