Activities of N,N′-Diarylurea MMV665852 Analogs against Schistosoma mansoni

There is an unmet need to discover and develop novel antischistosomal drugs. As exemplified by MMV665852, N,N′-diarylureas have recently emerged as a promising antischistosomal chemotype. In this study, we evaluated the structure-activity relationships of 46 commercially available analogs of MMV6658...

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Publicat a:Antimicrob Agents Chemother
Autors principals: Cowan, Noemi, Dätwyler, Philipp, Ernst, Beat, Wang, Chunkai, Vennerstrom, Jonathan L., Spangenberg, Thomas, Keiser, Jennifer
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2015
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356791/
https://ncbi.nlm.nih.gov/pubmed/25583726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04463-14
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