Subtle Changes in Endochin-Like Quinolone Structure Alter the Site of Inhibition within the Cytochrome bc(1) Complex of Plasmodium falciparum

The cytochrome bc(1) complex (cyt bc(1)) is the third component of the mitochondrial electron transport chain and is the target of several potent antimalarial compounds, including the naphthoquinone atovaquone (ATV) and the 4(1H)-quinolone ELQ-300. Mechanistically, cyt bc(1) facilitates the transfer...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Antimicrob Agents Chemother
Prif Awduron: Stickles, Allison M., de Almeida, Mariana Justino, Morrisey, Joanne M., Sheridan, Kayla A., Forquer, Isaac P., Nilsen, Aaron, Winter, Rolf W., Burrows, Jeremy N., Fidock, David A., Vaidya, Akhil B., Riscoe, Michael K.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Microbiology 2015
Pynciau:
Mechanisms of Action: Physiological Effects
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356778/
https://ncbi.nlm.nih.gov/pubmed/25605352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.04149-14
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