A Novel Antimycobacterial Compound Acts as an Intracellular Iron Chelator

Efficient iron acquisition is crucial for the pathogenesis of Mycobacterium tuberculosis. Mycobacterial iron uptake and metabolism are therefore attractive targets for antitubercular drug development. Resistance mutations against a novel pyrazolopyrimidinone compound (PZP) that is active against M....

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Publicado en:Antimicrob Agents Chemother
Autores principales: Dragset, Marte S., Poce, Giovanna, Alfonso, Salvatore, Padilla-Benavides, Teresita, Ioerger, Thomas R., Kaneko, Takushi, Sacchettini, James C., Biava, Mariangela, Parish, Tanya, Argüello, José M., Steigedal, Magnus, Rubin, Eric J.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2015
Materias:
Mechanisms of Action: Physiological Effects
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356758/
https://ncbi.nlm.nih.gov/pubmed/25645825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05114-14
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