A Novel Antimycobacterial Compound Acts as an Intracellular Iron Chelator

Efficient iron acquisition is crucial for the pathogenesis of Mycobacterium tuberculosis. Mycobacterial iron uptake and metabolism are therefore attractive targets for antitubercular drug development. Resistance mutations against a novel pyrazolopyrimidinone compound (PZP) that is active against M....

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Detaylı Bibliyografya
Yayımlandı:Antimicrob Agents Chemother
Asıl Yazarlar: Dragset, Marte S., Poce, Giovanna, Alfonso, Salvatore, Padilla-Benavides, Teresita, Ioerger, Thomas R., Kaneko, Takushi, Sacchettini, James C., Biava, Mariangela, Parish, Tanya, Argüello, José M., Steigedal, Magnus, Rubin, Eric J.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2015
Konular:
Mechanisms of Action: Physiological Effects
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356758/
https://ncbi.nlm.nih.gov/pubmed/25645825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05114-14
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