A Novel Antimycobacterial Compound Acts as an Intracellular Iron Chelator

Efficient iron acquisition is crucial for the pathogenesis of Mycobacterium tuberculosis. Mycobacterial iron uptake and metabolism are therefore attractive targets for antitubercular drug development. Resistance mutations against a novel pyrazolopyrimidinone compound (PZP) that is active against M....

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Vydáno v:Antimicrob Agents Chemother
Hlavní autoři: Dragset, Marte S., Poce, Giovanna, Alfonso, Salvatore, Padilla-Benavides, Teresita, Ioerger, Thomas R., Kaneko, Takushi, Sacchettini, James C., Biava, Mariangela, Parish, Tanya, Argüello, José M., Steigedal, Magnus, Rubin, Eric J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2015
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Mechanisms of Action: Physiological Effects
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4356758/
https://ncbi.nlm.nih.gov/pubmed/25645825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05114-14
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