Anti-melanoma vaccines engineered to simultaneously modulate cytokine priming and silence PD-L1 characterized using ex vivo myeloid-derived suppressor cells as a readout of therapeutic efficacy

Efficacious antitumor vaccines strongly stimulate cancer-specific effector T cells and counteract the activity of tumor-infiltrating immunosuppressive cells. We hypothesised that combining cytokine expression with silencing programmed cell death ligand 1 (PD-L1) could potentiate anticancer immune re...

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Detalhes bibliográficos
Publicado no:Oncoimmunology
Main Authors: Liechtenstein, Therese, Perez-Janices, Noemi, Blanco-Luquin, Idoia, Goyvaerts, Cleo, Schwarze, Julia, Dufait, Ines, Lanna, Alessio, Ridder, Mark De, Guerrero-Setas, David, Breckpot, Karine, Escors, David
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2014
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355828/
https://ncbi.nlm.nih.gov/pubmed/25954597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/21624011.2014.945378
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