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PD-L1/PD-1 Co-Stimulation, a Brake for T cell Activation and a T cell Differentiation Signal
For T cell activation, three signals have to be provided from the antigen presenting cell; Signal 1 (antigen recognition), signal 2 (co-stimulation) and signal 3 (cytokine priming). Blocking negative co-stimulation during antigen presentation to T cells is becoming a promising therapeutic strategy t...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2012
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3605779/ https://ncbi.nlm.nih.gov/pubmed/23525238 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4172/2155-9899.S12-006 |
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