Detection of germline mutations of hMLH1 and hMSH2 based on cDNA sequencing in China

AIM: To detect the germline mutations of hMLH1 and hMSH2 based on mRNA sequencing to identify hereditary non-polyposis colorectal cancer (HNPCC) families. METHODS: Total RNA was extracted from peripheral blood of 14 members from 12 different families fulfilling Amsterdam criteria II. mRNA of hMLH1 a...

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Bibliographic Details
Published in:World J Gastroenterol
Main Authors: Wang, Chao-Fu, Zhou, Xiao-Yan, Zhang, Tai-Ming, Sun, Meng-Hong, Shi, Da-Ren
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Inc 2005
Subjects:
Colorectal Cancer
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355754/
https://ncbi.nlm.nih.gov/pubmed/16425354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v11.i42.6620
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