Prevention of exercised induced cardiomyopathy following Pip-PMO treatment in dystrophic mdx mice

Duchenne muscular dystrophy (DMD) is a fatal neuromuscular disorder caused by mutations in the Dmd gene. In addition to skeletal muscle wasting, DMD patients develop cardiomyopathy, which significantly contributes to mortality. Antisense oligonucleotides (AOs) are a promising DMD therapy, restoring...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Betts, Corinne A., Saleh, Amer F., Carr, Carolyn A., Hammond, Suzan M., Coenen-Stass, Anna M. L., Godfrey, Caroline, McClorey, Graham, Varela, Miguel A., Roberts, Thomas C., Clarke, Kieran, Gait, Michael J., Wood, Matthew J. A.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355666/
https://ncbi.nlm.nih.gov/pubmed/25758104
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep08986
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