Innate Immune Response to Streptococcus pyogenes Depends on the Combined Activation of TLR13 and TLR2

Innate immune recognition of the major human-specific Gram-positive pathogen Streptococcus pyogenes is not understood. Here we show that mice employ Toll-like receptor (TLR) 2- and TLR13-mediated recognition of S. pyogenes. These TLR pathways are non-redundant in the in vivo context of animal infect...

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Pubblicato in:PLoS One
Autori principali: Fieber, Christina, Janos, Marton, Koestler, Tina, Gratz, Nina, Li, Xiao-Dong, Castiglia, Virginia, Aberle, Marion, Sauert, Martina, Wegner, Mareike, Alexopoulou, Lena, Kirschning, Carsten J., Chen, Zhijian J., von Haeseler, Arndt, Kovarik, Pavel
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355416/
https://ncbi.nlm.nih.gov/pubmed/25756897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119727
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