Granzyme B Expression is Enhanced in Human Monocytes by TLR8 Agonists and Contributes to ADCC()

Fcγ receptors (FcγR) are critical mediators of monoclonal antibody cancer therapies, as they drive cytotoxic processes upon binding of effector cells to opsonized targets. Along with natural killer (NK) cells, monocytes are also known to destroy antibody-coated targets via antibody-dependent cellula...

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Publicado no:J Immunol
Main Authors: Elavazhagan, Saranya, Fatehchand, Kavin, Santhanam, Vikram, Fang, Huiqing, Ren, Li, Gautam, Shalini, Reader, Brenda, Mo, Xiaokui, Cheney, Carolyn, Briercheck, Edward, Vasilakos, John P., Dietsch, Gregory N., Hershberg, Robert M., Caligiuri, Michael, Byrd, John C., Butchar, Jonathan P., Tridandapani, Susheela
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4355383/
https://ncbi.nlm.nih.gov/pubmed/25667415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402316
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