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Dynamic knockdown of E. coli central metabolism for redirecting fluxes of primary metabolites
Control of native enzyme levels is important when optimizing strains for overproduction of heterologous compounds. However, for many central metabolic enzymes, static knockdown results in poor growth and protein expression. We have developed a strategy for dynamically modulating the abundance of nat...
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| Publicado no: | Metab Eng |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4355230/ https://ncbi.nlm.nih.gov/pubmed/25542851 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymben.2014.12.005 |
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