Coupling of T cell receptor specificity to natural killer T cell development by bivalent histone H3 methylation

The fidelity of T cell immunity depends greatly on coupling T cell receptor signaling with specific T cell effector functions. Here, we describe a chromatin-based mechanism that enables integration of TCR specificity into definite T cell lineage commitment. Using natural killer T cells (iNKT cell) a...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Exp Med
Main Authors: Dobenecker, Marc-Werner, Kim, Jong Kyong, Marcello, Jonas, Fang, Terry C., Prinjha, Rab, Bosselut, Remy, Tarakhovsky, Alexander
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2015
Teme:
Brief Definitive Report
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4354372/
https://ncbi.nlm.nih.gov/pubmed/25687282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20141499
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