Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning.
Transgenic mice designated alpha MUPA overproduce in the brain murine urokinase-type plasminogen activator (uPA), an extracellular protease implicated in tissue remodeling. We have now localized, by in situ hybridization, extensive signal of uPA mRNA in the alpha MUPA cortex, hippocampus, and amygda...
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| 發表在: | Proc Natl Acad Sci U S A |
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| Principais autores: | , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
National Academy of Sciences
1994
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43542/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8159723/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.8.3196 |
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