Overexpression of urokinase-type plasminogen activator in transgenic mice is correlated with impaired learning.

Transgenic mice designated alpha MUPA overproduce in the brain murine urokinase-type plasminogen activator (uPA), an extracellular protease implicated in tissue remodeling. We have now localized, by in situ hybridization, extensive signal of uPA mRNA in the alpha MUPA cortex, hippocampus, and amygda...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Meiri, N, Masos, T, Rosenblum, K, Miskin, R, Dudai, Y
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 1994
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC43542/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8159723/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.8.3196
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