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Neuroprotection by urokinase plasminogen activator in the hippocampus

Tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which are both used for thrombolytic treatment of acute ischemic stroke, are serine proteases that convert plasminogen to active plasmin. Although recent experimental evidences have raised controversy about the neurotoxic...

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Principais autores: Eunsil Cho, Kyung Jin Lee, Jung-Woo Seo, Catherine Jeonghae Byun, Sun-Ju Chung, Dae Chul Suh, Peter Carmeliet, Jae-Young Koh, Jong S. Kim, Joo-Yong Lee
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2012-04-01
coleção:Neurobiology of Disease
Assuntos:
Plasminogen activators (PAs)
Epileptic seizures
Kainic acid
Excitotoxicity
Gliosis
Acute brain injury
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S0969996112000253
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