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Neuroprotection by urokinase plasminogen activator in the hippocampus

Tissue plasminogen activator (tPA) and urokinase plasminogen activator (uPA), which are both used for thrombolytic treatment of acute ischemic stroke, are serine proteases that convert plasminogen to active plasmin. Although recent experimental evidences have raised controversy about the neurotoxic...

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Autori principali: Eunsil Cho, Kyung Jin Lee, Jung-Woo Seo, Catherine Jeonghae Byun, Sun-Ju Chung, Dae Chul Suh, Peter Carmeliet, Jae-Young Koh, Jong S. Kim, Joo-Yong Lee
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2012-04-01
Serie:Neurobiology of Disease
Soggetti:
Plasminogen activators (PAs)
Epileptic seizures
Kainic acid
Excitotoxicity
Gliosis
Acute brain injury
Accesso online:http://www.sciencedirect.com/science/article/pii/S0969996112000253
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