Rare Autism-Associated Variants Implicate Syntaxin 1 (STX1 R26Q) Phosphorylation and the Dopamine Transporter (hDAT R51W) in Dopamine Neurotransmission and Behaviors

BACKGROUND: Syntaxin 1 (STX1) is a presynaptic plasma membrane protein that coordinates synaptic vesicle fusion. STX1 also regulates the function of neurotransmitter transporters, including the dopamine (DA) transporter (DAT). The DAT is a membrane protein that controls DA homeostasis through the hi...

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Detalhes bibliográficos
Publicado no:EBioMedicine
Main Authors: Cartier, Etienne, Hamilton, Peter J., Belovich, Andrea N., Shekar, Aparna, Campbell, Nicholas G., Saunders, Christine, Andreassen, Thorvald F., Gether, Ulrik, Veenstra-Vanderweele, Jeremy, Sutcliffe, James S., Ulery-Reynolds, Paula G., Erreger, Kevin, Matthies, Heinrich J.G., Galli, Aurelio
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2015
Assuntos:
Original Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353922/
https://ncbi.nlm.nih.gov/pubmed/25774383
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ebiom.2015.01.007
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