Zn(2+) reverses functional deficits in a de novo dopamine transporter variant associated with autism spectrum disorder

Our laboratory recently characterized a novel autism spectrum disorder (ASD)-associated de novo missense mutation in the human dopamine transporter (hDAT) gene SLC6A3 (hDAT T356M). This hDAT variant exhibits dysfunctional forward and reverse transport properties that may contribute to DA dysfunction...

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Vydáno v:Mol Autism
Hlavní autoři: Hamilton, Peter J, Shekar, Aparna, Belovich, Andrea N, Christianson, Nicole Bibus, Campbell, Nicholas G, Sutcliffe, James S, Galli, Aurelio, Matthies, Heinrich JG, Erreger, Kevin
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2015
Témata:
Letter to the Editor
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4349303/
https://ncbi.nlm.nih.gov/pubmed/25741436
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13229-015-0002-7
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