The TLQP-21 Peptide Activates the G-protein-coupled receptor C3aR1 via a Folding-upon-Binding Mechanism

TLQP-21, a VGF-encoded peptide is emerging as a novel target for obesity-associated disorders. TLQP-21 is found in the sympathetic nerve terminals in the adipose tissue and targets the G-protein-coupled-receptor (GPCR) Complement-3a-Receptor1 (C3aR1). So far, the mechanisms of TLQP-21-induced recept...

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Gepubliceerd in:Structure
Hoofdauteurs: Cero, Cheryl, Vostrikov, Vitaly V., Verardi, Raffaello, Severini, Cinzia, Gopinath, Tata, Braun, Patrick D., Sassano, Maria F., Gurney, Allison, Roth, Bryan L., Vulchanova, Lucy, Possenti, Roberta, Veglia, Gianluigi, Bartolomucci, Alessandro
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2014
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353613/
https://ncbi.nlm.nih.gov/pubmed/25456411
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2014.10.001
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