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Structural dynamics and topology of phosphorylated phospholamban homopentamer reveal its role in the regulation of calcium transport in sarcoplasmic reticulum

Phospholamban (PLN) inhibits the sarco(endo)plasmic reticulum Ca(2+)-ATPase (SERCA), thereby regulating cardiac diastole. In membranes, PLN assembles into homopentamers that in both the phosphorylated and non-phosphorylated states have been proposed to form ion-selective channels. Here, we determine...

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Bibliografiske detaljer
Main Authors: Vostrikov, Vitaly V., Mote, Kaustubh R., Verardi, Raffaello, Veglia, Gianluigi
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3951103/
https://ncbi.nlm.nih.gov/pubmed/24207128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2013.09.008
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