Damage-induced BRCA1 phosphorylation by Chk2 contributes to the timing of end resection

The BRCA1 tumor suppressor plays an important role in homologous recombination (HR)-mediated DNA double-strand-break (DSB) repair. BRCA1 is phosphorylated by Chk2 kinase upon γ-irradiation, but the role of Chk2 phosphorylation is not understood. Here, we report that abrogation of Chk2 phosphorylatio...

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Bibliografiske detaljer
Udgivet i:Cell Cycle
Main Authors: Parameswaran, Balaji, Chiang, Huai-Chin, Lu, Yunzhe, Coates, Julia, Deng, Chu-Xia, Baer, Richard, Lin, Hui-Kuan, Li, Rong, Paull, Tanya T, Hu, Yanfen
Format: Artigo
Sprog:Inglês
Udgivet: Taylor & Francis 2015
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Reports
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4353239/
https://ncbi.nlm.nih.gov/pubmed/25659039
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.972901
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