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A dynamic exchange of TCF3 and TCF4 transcription factors controls MYC expression in colorectal cancer cells
Deregulated Wnt/β-catenin signaling promotes colorectal cancer (CRC) by activating expression of the c-MYC proto-oncogene (MYC). In the nucleus, the β-catenin transcriptional co-activator binds T-cell factor (TCF) transcription factors, and together TCF/β-catenin complexes activate MYC expression th...
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| Veröffentlicht in: | Cell Cycle |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Taylor & Francis
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4353228/ https://ncbi.nlm.nih.gov/pubmed/25659031 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4161/15384101.2014.980643 |
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