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Nuclear AXIN2 represses MYC gene expression
The β-catenin transcriptional coactivator is the key mediator of the canonical Wnt signaling pathway. In the absence of Wnt, β-catenin associates with a cytosolic and multi-protein destruction complex where it is phosphorylated and targeted for proteasomal degradation. In the presence of Wnt, the de...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3950968/ https://ncbi.nlm.nih.gov/pubmed/24299953 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2013.11.089 |
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