Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

Glioblastoma (GBM) is a prototypical heterogeneous brain tumor refractory to conventional therapy. A small residual population of cells escapes surgery and chemoradiation, resulting in a typically fatal tumor recurrence ∼7 mo after diagnosis. Understanding the molecular architecture of this residual...

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Dades bibliogràfiques
Publicat a:Genome Res
Autors principals: Kim, Hoon, Zheng, Siyuan, Amini, Seyed S., Virk, Selene M., Mikkelsen, Tom, Brat, Daniel J., Grimsby, Jonna, Sougnez, Carrie, Muller, Florian, Hu, Jian, Sloan, Andrew E., Cohen, Mark L., Van Meir, Erwin G., Scarpace, Lisa, Laird, Peter W., Weinstein, John N., Lander, Eric S., Gabriel, Stacey, Getz, Gad, Meyerson, Matthew, Chin, Lynda, Barnholtz-Sloan, Jill S., Verhaak, Roel G.W.
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2015
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352879/
https://ncbi.nlm.nih.gov/pubmed/25650244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.180612.114
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