GE-17 ALTERATION OF THE p53 PATHWAY AND ANCESTRAL PROGENITORS ARE ASSOCIATED WITH TUMOR RECURRENCE IN GLIOBLASTOMA

To evaluate evolutionary patterns of GBM recurrence, we analyzed whole genome sequencing (WGS) and multi-sector exome sequencing data from pairs of primary and posttreatment GBM. WGS on ten primary-recurrent pairs detected a median number of 12,214 mutations which we utilized to uncover clonal struc...

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Bibliografiske detaljer
Main Authors: Kim, Hoon, Zheng, Siyuan, Amini, Seyed, Virk, Selene, Mikkelsen, Tom, Brat, Daniel, Sougnez, Carrie, Muller, Florian, Hu, Jian, Sloan, Andrew, Cohen, Mark, Van Meir, Erwin, Scarpace, Lisa, Lander, Eric, Gabriel, Stacey, Getz, Gad, Meyerson, Matthew, Chin, Lynda, Barnholtz-Sloan, Jill, Verhaak, Roel
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2014
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Abstracts
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4218181/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou256.17
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