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Whole-genome and multisector exome sequencing of primary and post-treatment glioblastoma reveals patterns of tumor evolution

Glioblastoma (GBM) is a prototypical heterogeneous brain tumor refractory to conventional therapy. A small residual population of cells escapes surgery and chemoradiation, resulting in a typically fatal tumor recurrence ∼7 mo after diagnosis. Understanding the molecular architecture of this residual...

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Detalhes bibliográficos
Publicado no:Genome Res
Main Authors: Kim, Hoon, Zheng, Siyuan, Amini, Seyed S., Virk, Selene M., Mikkelsen, Tom, Brat, Daniel J., Grimsby, Jonna, Sougnez, Carrie, Muller, Florian, Hu, Jian, Sloan, Andrew E., Cohen, Mark L., Van Meir, Erwin G., Scarpace, Lisa, Laird, Peter W., Weinstein, John N., Lander, Eric S., Gabriel, Stacey, Getz, Gad, Meyerson, Matthew, Chin, Lynda, Barnholtz-Sloan, Jill S., Verhaak, Roel G.W.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352879/
https://ncbi.nlm.nih.gov/pubmed/25650244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.180612.114
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