RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels

Following their synthesis in the endoplasmic reticulum (ER), voltage-gated sodium channels (Na(V)) are transported to the membranes of excitable cells, where they often cluster, such as at the axon initial segment of neurons. Although the mechanisms by which Na(V) channels form and maintain clusters...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Ogino, Kazutoyo, Low, Sean E., Yamada, Kenta, Saint-Amant, Louis, Zhou, Weibin, Muto, Akira, Asakawa, Kazuhide, Nakai, Junichi, Kawakami, Koichi, Kuwada, John Y., Hirata, Hiromi
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2015
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352840/
https://ncbi.nlm.nih.gov/pubmed/25691753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414002112
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