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RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels

Following their synthesis in the endoplasmic reticulum (ER), voltage-gated sodium channels (Na(V)) are transported to the membranes of excitable cells, where they often cluster, such as at the axon initial segment of neurons. Although the mechanisms by which Na(V) channels form and maintain clusters...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Ogino, Kazutoyo, Low, Sean E., Yamada, Kenta, Saint-Amant, Louis, Zhou, Weibin, Muto, Akira, Asakawa, Kazuhide, Nakai, Junichi, Kawakami, Koichi, Kuwada, John Y., Hirata, Hiromi
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352840/
https://ncbi.nlm.nih.gov/pubmed/25691753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1414002112
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