Structural assembly of the signaling competent ERK2–RSK1 heterodimeric protein kinase complex

Mitogen-activated protein kinases (MAPKs) bind and activate their downstream kinase substrates, MAPK-activated protein kinases (MAPKAPKs). Notably, extracellular signal regulated kinase 2 (ERK2) phosphorylates ribosomal S6 kinase 1 (RSK1), which promotes cellular growth. Here, we determined the crys...

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Dettagli Bibliografici
Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Alexa, Anita, Gógl, Gergő, Glatz, Gábor, Garai, Ágnes, Zeke, András, Varga, János, Dudás, Erika, Jeszenői, Norbert, Bodor, Andrea, Hetényi, Csaba, Reményi, Attila
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352816/
https://ncbi.nlm.nih.gov/pubmed/25730857
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1417571112
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